Publications

We had 15 people working at the coordinating center of the trial and over 60 nurses who examined the participants at home or in the hospital. Approximately 50 students contributed to the study.

Peer-reviewed publications on omega-3 fatty acids and cardiovascular events in the Alpha Omega Trial

  • Hoogeveen EK, Geleijnse JM, Giltay EJ, Soedamah-Muthu SS, de Goede J, Oude Griep LM, Stijnen T, Kromhout D. Kidney function and specific mortality in 60-80 years old post-myocardial infarction patients: A 10-year follow-up study. PLoS ONE 2017;12:e0171868.
  • Heeres RH, Hoogeveen EK, Geleijnse JM, de Goede J, Kromhout D, Giltay EJ. Kidney dysfunction, systemic inflammation and mental well-being in elderly post-myocardial infarction patients. BMC Psychol 2017;5:1-10.
  • Eussen SRBM, Geleijnse JM, Giltay EJ, Rompelberg CJM, Klungel OH, Kromhout D. Effects of n-3 fatty acids on major cardiovascular events in statin users and non-users with a history of myocardial infarction. Eur Heart J 2012;33:1582–1588.
  • Kromhout D, Boer M-J de. Response to comment on: Kromhout et al. n-3 Fatty acids, ventricular arrhythmia-related events and fatal myocardial infarction in postmyocardial infarction patients with diabetes. Diabetes Care 2012;6:E46.
  • Kromhout D, Geleijnse JM, de Goede J, Oude Griep LM, Mulder BJM, de Boer M-J, Deckers JW, Boersma E, Zock PL, Giltay EJ. N-3 fatty acids, ventricular arrhythmia related events, and fatal myocardial infarction in postmyocardial infarction patients with diabetes. Diabetes Care 2011;34:2515-2520.
  • Kromhout D, Giltay EJ, Geleijnse JM. N-3 Fatty acids and cardiovascular events. Reply to letters to the editor. N Engl J Med 2011;364:880-881.
  • Kromhout D, Giltay EJ, Geleijnse JM for the Alpha Omega Trial Group. n–3 fatty acids and cardiovascular events after myocardial infarction. N Engl J Med 2010;363:2015-2026.
  • Geleijnse JM, Giltay EJ, Schouten EG, de Goede J, Oude Griep LM, Teitsma-Jansen AM, Katan MB, Kromhout D for the Alpha Omega Trial Group. Effect of low doses of n-3 fatty acids on cardiovascular diseases in 4,837 post-myocardial infarction patients: design and baseline characteristics of the Alpha Omega Trial. Am Heart J 2010;159:539-546.

Peer-reviewed articles about omega-3 fatty acids and non-cardiovascular endpoints in the Alpha Omega Trial

  • Hoogeveen EK, Geleijnse JM, Kromhout D, Van’t Sant P, Gemen EF, Kusters R, Giltay EJ. No effect of n-3 fatty acids supplementation on NT-proBNP after myocardial infarction: The Alpha Omega Trial. Eur J Prev Cardiol 2014;22:648-55.
  • Hoogeveen EK, Geleijnse JM, Kromhout D, Stijnen T, Gemen EF, Kusters R, Giltay EJ. Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial. Clin J Am Soc Nephrol 2014;9:1676-83.
  • Hoogeveen EK, Geleijnse JM, Kromhout D, Giltay EJ. No effect of n-3 fatty acids on high-sensitivity C-reactive protein after myocardial infarction: The Alpha Omega Trial. Eur J Prev Cardiol 2014;21:1429-36.
  • Brouwer IA, Geleijnse JM, Klaasen VM, Smit LA, Giltay EJ, Goede J de, Heijboer AC, Kromhout D, Katan MB. Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): Results from the Alpha Omega Trial. PLoS One 2013;8:e81519.
  • Geleijnse JM, Giltay EJ, Kromhout D. Effects of n-3 fatty acids on cognitive decline: A randomized, double-blind, placebo-controlled trial in stable myocardial infarction patients. Alzheimer´s Dementia 2012;8:278–287.
  • Giltay EJ, Geleijnse JM, Heijboer AC, Goede J de, Oude Griep LM, Blankenstein MA, Kromhout D. No effects of n-3 fatty acid supplementation on serum total testosterone levels in older men: the Alpha Omega Trial. Int J Androl 2012;35:680-7.
  • Giltay EJ, Geleijnse JM, Kromhout D. Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction. Am J Clin Nutr 2011;94:1442–1450.

Peer-reviewed articles about observational analyses in the Alpha Omega Trial

  • Hoogeveen EK, Geleijnse JM, Giltay EJ, Soedamah-Muthu SS, de Goede J, Oude Griep LM, Stijnen T, Kromhout D. Kidney function and specific mortality in 60-80 years old post-myocardial infarction patients: A 10-year follow-up study. PLoS ONE 2017;12:e0171868.
  • Heeres RH, Hoogeveen EK, Geleijnse JM, de Goede J, Kromhout D, Giltay EJ. Kidney dysfunction, systemic inflammation and mental well-being in elderly post-myocardial infarction patients. BMC Psychol 2017;5:1-10.
  • Sijtsma FP, Soedamah-Muthu SS, de Goede J, Oude Griep LM, Geleijnse JM, Giltay EJ, de Boer MJ, Jacobs DR Jr, Kromhout D. Healthy eating and lower mortality risk in a large cohort of cardiac patients who received state-of-the-art drug treatment. Am J Clin Nutr 2015;105:1527-33.
  • Rius-Ottenheim N, Geleijnse JM, Kromhout D, van der Mast RC, Zitman FG, Giltay EJ. Physical activity after myocardial infarction: is it related to mental health? Eur J Prev Cardiol 2013;20:399-408.
  • Rius-Ottenheim N, Kromhout D, Craen AJM de, Geleijnse JM, Mast RC van der, Zitman FG, Westendorp RG, Slagboom PE, Giltay EJ. Parental longevity correlates with offspring’s optimism in two cohorts of community-dwelling older subjects. Age & Aging 2012;34:461–468.
  • Soedamah-Muthu SS, Geleijnse JM, Giltay EJ, Kromhout D. Cardiovascular risk factor management of myocardial infarction patients with and without diabetes in the Netherlands between 2002 and 2006: a cross-sectional analysis of baseline data. BMJ open 2012;31:2-6.
  • Soedamah-Muthu SS, Geleijnse JM, Giltay EJ, Goede J de, Oude Griep LM, Waterham E, Teitsma-Jansen AM, Mulder BJM, Boer MJ de, Deckers JW, Zock PL, Kromhout D  for the  Alpha Omega Trial Group. Levels and trends in cardiovascular risk factors and drug treatment in 4837 elderly Dutch myocardial infarction patients between 2002 and 2006. Neth Heart J 2012;20:102–109.
  • Van de Rest O, de Goede J, Sytsma F, Oude Griep LM, Geleijnse JM, Kromhout D, Giltay EJ. Association of n-3 long-chain PUFA and fish intake with depressive symptoms and low dispositional optimism in older subjects with a history of myocardial infarction. Br J Nutr 2010;103:1381-1387.
  • De Jong HJI, de Goede J, Oude Griep LM, Geleijnse JM. Alcohol consumption and blood lipids in elderly coronary patients. Metabolism 2008;57:1286-1292.
  • Giltay EJ, Geleijnse JM, Schouten EG, Katan MB, Kromhout D. High stability of markers of cardiovascular risk in blood samples. Clin Chem 2003;49:652-655.

Other peer-reviewed publications on fish and omega-3 fatty acids by our group

  • Kromhout D. Goede J de. Update on cardiometabolic health effects of ω-3 fatty acids. Curr Opin Lipidol 2014;25:85–90.
  • Goede J de, Verschuren WM, Boer JM, Kromhout D, Geleijnse JM. N-6 and n-3 fatty acid cholesteryl esters in relation to incident stroke in a Dutch adult population: a nested case-control study. Nutr Metab Cardiovasc Dis. 2013;23:737-43.
  • Goede J de, Verschuren WM, Boer JM, Verberne LD, Kromhout D, Geleijnse JM. N-6 and N-3 fatty acid cholesteryl esters in relation to fatal CHD in a Dutch adult population: a nested case-control study and meta-analysis. PLoS One. 2013;8:e59408.
  • Goede J de, Geleijnse JM. The role of fatty acids from fish in the prevention  of stroke. BMJ. 2012;345:e7219. 
  • Kromhout D. Omega-3 fatty acids and coronary heart disease. The final verdict? Curr Opin Lipidol 2012;23:554-559.
  • Kromhout D, Yasuda S, Geleijnse JM, Shimokawa H. Fish oil and omega-3 fatty acids in cardiovascular disease: do they really work? Eur Heart J 2012;33:436-443.
  • Goede J de, Verschuren WM, Boer JM, Kromhout D, Geleijnse JM. Gender-specific associations of marine n-3 fatty acids and fish consumption with 10-year incidence of stroke. PLoS One. 2012;7:e33866. 
  • Goede J de, Verschuren WM, Boer JM, Kromhout D, Geleijnse JM. Alpha-linolenic acid intake and 10-year incidence of coronary heart disease and stroke in 20,000 middle-aged men and women in the Netherlands. PLoS One. 2011;6:e17967.

  • Hirai Y, Geleijnse JM, Adachi H, Imaizumi T, Kromhout D. Systolic blood pressure predicts cardiovascular mortality in a farming but not in a fishing community. -A 40-year follow up of the Japanese cohorts of the seven countries study-. Circulation J. 2011;75:1890-1896.
  • Kromhout D, Geleijnse JM, Menotti A, Jacobs DR Jr. The confusion about dietary fatty acids recommendations for CHD prevention. Br J Nutr. 2011;106:627-632.
  • Geleijnse JM, Goede J de, Brouwer IA. Alpha-linolenic acid: is it essential to cardiovascular health? Curr Atheroscler Rep. 2010;12:359-367.

  • Goede J de, Geleijnse JM, Boer JMA, Kromhout D, Verschuren WMM. Marine (n-3) fatty acids, fish consumption, and the 10-year risk of fatal and nonfatal coronary heart disease in a large population of Dutch adults with a low fish intake. J Nutr 2010;140:1023-1028.

  • Heine-Bröring RC, Brouwer IA, Proença RV, van Rooij FJ, Hofman A, Oudkerk M, Witteman JC, Geleijnse JM. Intake of fish and marine n-3 fatty acids in relation  to coronary calcification: the Rotterdam Study. Am J Clin Nutr. 2010;91:1317-23.
  • Bouwens M, Rest O van de, Dellschaft N, Bromhaar MG, de Groot LC, Geleijnse JM, Müller M, Afman LA. Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells. Am J Clin Nutr. 2009;90:415-424.
  • Dijkstra SC, Brouwer IA, van Rooij FJ, Hofman A, Witteman JC, Geleijnse JM. Intake of very long chain n-3 fatty acids from fish and the incidence of heart failure: the Rotterdam Study. Eur J Heart Fail. 2009;11:922-928.
  • Rest O van de, Spiro A 3rd, Krall-Kaye E, Geleijnse JM, de Groot LC, Tucker KL. Intakes of (n-3) fatty acids and fatty fish are not associated with cognitive performance and 6-year cognitive change in men participating in the Veterans Affairs Normative Aging Study. J Nutr. 2009;139:2329-2336.
  • Rest O van de, Geleijnse JM, Kok FJ, van Staveren WA, Olderikkert MG, Beekman AT, de Groot LC. Effect of fish oil supplementation on quality of life in a general population of older Dutch subjects: a randomized, double-blind, placebo-controlled trial. J Am Geriatr Soc. 2009;57:1481-1486.
  • Woudenbergh GJ van, van Ballegooijen AJ, Kuijsten A, Sijbrands EJ, van Rooij FJ, Geleijnse JM, Hofman A, Witteman JC, Feskens EJ. Eating fish and risk of type 2 diabetes: A population-based, prospective follow-up study. Diabetes Care. 2009 ;32:2021-2026.
  • Rest O van de, Geleijnse JM, Kok FJ, van Staveren WA, Dullemeijer C, Olderikkert MG, Beekman AT, de Groot CP. Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial. Neurology. 2008;71:430-438.
  • Rest O van de, Geleijnse JM, Kok FJ, van Staveren WA, Hoefnagels WH, Beekman AT, de Groot LC. Effect of fish-oil supplementation on mental well-being in older subjects: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2008;88:706-713. 
  • Streppel MT, Ocke MC, Boshuizen HC, Kok FJ, Kromhout D. Long-term fish consumption and n-3 fatty acids in relation to (sudden) coronary heart disease death: the Zutphen study. Eur Heart J 2008;29;2024-2030.
  • Gelder BM van, Tijhuis M, Kalmijn S, Kromhout D. Fish, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men. The Zutphen Elderly Study. Am J Clin Nutr 2007;85:1142-1147.
  • Brouwer IA, Heeringa J, Geleijnse JM, Zock PL, Witteman JC. Intake of very long-chain n-3 fatty acids from fish and incidence of atrial fibrillation. The Rotterdam Study. Am Heart J. 2006;151:857-862.
  • Geleijnse JM, Brouwer IA, Feskens EJ. Risks and benefits of omega 3 fats: health benefits of omega 3 fats are in doubt. BMJ 2006;332:915.
  • Kamphuis MH, Geerlings MI, Tijhuis MAR, Kalmijn S, Grobbee DE, Kromhout D. Depression and cardiovascular mortality: a role for n-3 fatty acids? Am J Clin Nutr 2006;84:400-405.
  • Kromhout D. Fish consumption, N-3 fatty acids and coronary heart disease. In: Coronary heart disease epidemiology. From aetiology to public health. Marmot M, Elliott P (eds). Oxford University Press, ISBN 0198568061, 2005:264-274.
  • Mozaffarian D, Geelen A, Brouwer IA, Geleijnse JM, Zock PL, Katan MB. Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials. Circulation. 2005;112:1945-1952. 
  • Geleijnse JM, Giltay EJ, Grobbee DE, Donders AR, Kok FJ. Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens. 2002;20:1493-1499. 
  • Oomen CM, Ocké MC, Feskens EJM, Kok FJ, Kromhout D. alpha-Linolenic acid intake is not beneficially associated with 10-y risk of coronary artery disease incidence: the Zutphen Elderly Study. Am J Clin Nutr 2001;74:457-463.
  • Oomen CM, Feskens EJM, Räsänen L, Fidanza F, Nissinen AM, Menotti A, Kok FJ, Kromhout D. Fish consumption and coronary heart disease mortality in Finland, Italy and the Netherlands. Am J Epidemiol 2000;151:999-1006.
  • Kromhout D. Fish consumption and sudden cardiac death (editorial). JAMA 1998;279:65-66.
  • Kalmijn S, Feskens EJM, Launer LJ, Kromhout D. Polyunsaturated dietary fatty acids, antioxidants and cognitive function in very old men. Am J Epidemiol 1997;145:33-41.
  • Kromhout D, Katan MB, Havekes L, Groener A, Hornstra G, Lezenne Coulander C de. The effect of 26 years of habitual fish consumption on serum lipid and lipoprotein levels (The Zutphen Study). Nutr Metab Cardiovasc Dis 1996;2:65-73.
  • Kromhout D, Feskens EJM, Bowles CH. The protective effect of a small amount of fish on coronary heart disease mortality in an elderly population. Int J Epidemiol 1995;24:340-345.
  • Keli SO, Feskens EJM, Kromhout D. Fish consumption and risk of stroke (The Zutphen Study). Stroke 1994;25:328-332.
  • Houwelingen AC van, Hornstra G, Kromhout D, Lezenne Coulander C de. Habitual fish consumption, fatty acids of serum phospholipids and platelet function. Atherosclerosis 1989;75:157-165.
  • Kromhout D, Bosschieter EB, Lezenne Coulander C de. The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Eng J Med 1985;312:1205-1209.